Rooperol
| Code | Size | Price |
|---|
| TAR-T26121-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26121-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26121-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Rooperol is a norlignan derivative with numerous biological activities including immunomodulatory, antitumor, antibacterial, anticonvulsant, and antioxidant activities. It is a novel p38α inhibitor.
CAS:
83644-00-2
Formula:
C17H14O4
Molecular Weight:
282.295
Purity:
0.98
SMILES:
Oc1ccc(C=CCC#Cc2ccc(O)c(O)c2)cc1O
References
1. Ali Azouaou S, Emhemmed F, Idris-Khodja N, Lobstein A, Schini-Kerth V, Muller CD, Fuhrmann G. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells. Invest New Drugs. 2015 Feb;33(1):64-74. doi: 10.1007/s10637-014-0182-6. Epub 2014 Nov 19. PubMed PMID: 25404486.
2. Boukes GJ, van de Venter M. Rooperol as an antioxidant and its role in the innate immune system: an in vitro study. J Ethnopharmacol. 2012 Dec 18;144(3):692-9. doi: 10.1016/j.jep.2012.10.014. Epub 2012 Oct 17. PubMed PMID: 23085395.
3. Kabanda MM. Antioxidant activity of rooperol investigated through Cu (I and II) chelation ability and the hydrogen transfer mechanism: a DFT study. Chem Res Toxicol. 2012 Oct 15;25(10):2153-66. doi: 10.1021/tx300244z. Epub 2012 Sep 17. PubMed PMID: 22946567.
4. Li J, Kaoud TS, LeVieux J, Gilbreath B, Moharana S, Dalby KN, Kerwin SM. A fluorescence-based assay for p38? recruitment site binders: identification of rooperol as a novel p38? kinase inhibitor. Chembiochem. 2013 Jan 2;14(1):66-71. doi: 10.1002/cbic.201200529. Epub 2012 Dec 6. PubMed PMID: 23225637; PubMed Central PMCID: PMC3775607.