RU 43044
| Code | Size | Price |
|---|
| TAR-T26152-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
RU 43044 is a selective glucocorticoid receptor antagonist that has exhibited an antidepressant-like effect.
CAS:
136959-96-1
Formula:
C29H34O2
Molecular Weight:
414.589
Purity:
0.98
SMILES:
[H][C@]12CC[C@](O)(C#CC)[C@@]1(C)CC=C1[C@@]2([H])CCC2=CC(=O)CC[C@]12Cc1ccc(C)cc1
References
1. Ago Y, Arikawa S, Yata M, Yano K, Abe M, Takuma K, Matsuda T. Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression. Neuropharmacology. 2008 Dec;55(8):1355-63. doi: 10.1016/j.neuropharm.2008.08.026. Epub 2008 Aug 30. PubMed PMID: 18796307.
2. Ago Y, Arikawa S, Yata M, Yano K, Abe M, Takuma K, Matsuda T. Role of prefrontal dopaminergic neurotransmission in glucocorticoid receptor-mediated modulation of methamphetamine-induced hyperactivity. Synapse. 2009 Jan;63(1):7-14. doi: 10.1002/syn.20575. PubMed PMID: 18925659.
3. Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T. Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behav Pharmacol. 2015 Oct;26(7 Spec No):681-90. doi: 10.1097/FBP.0000000000000140. PubMed PMID: 25932719.
4. Schust DJ, Anderson DJ, Hill JA. Progesterone-induced immunosuppression is not mediated through the progesterone receptor. Hum Reprod. 1996 May;11(5):980-5. PubMed PMID: 8671374.