SNS-314 Mesylate

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TargetMol
Product Code: TAR-T2617
Supplier: TargetMol
CodeSizePrice
TAR-T2617-1mg1mg£102.00
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TAR-T2617-2mg2mg£113.00
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TAR-T2617-5mg5mg£138.00
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TAR-T2617-1mL1 mL * 10 mM (in DMSO)£153.00
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TAR-T2617-10mg10mg£173.00
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TAR-T2617-25mg25mg£269.00
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TAR-T2617-50mg50mg£345.00
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TAR-T2617-100mg100mg£470.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
SNS-314 Mesylate is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.
CAS:
1146618-41-8
Formula:
C19H19ClN6O4S3
Molecular Weight:
527.03
Pathway:
Cell Cycle/Checkpoint; Chromatin/Epigenetic
Purity:
0.9992
SMILES:
CS(O)(=O)=O.Clc1cccc(NC(=O)Nc2ncc(CCNc3ncnc4ccsc34)s2)c1
Target:
Aurora Kinase

References

1. Oslob JD, et al. Bioorg Med Chem Lett, 2008, 18(17), 4880-4884. 2. VanderPorten EC, et al. Mol Cancer Ther, 2009, 8(4), 930-939. 3. Arbitrario JP, et al. Cancer Chemother Pharmacol, 2010, 65(4), 707-717.