SB-217452
| Code | Size | Price |
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| TAR-T26178-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
SB-217452 is a potent seryl tRNA synthetase inhibitor isolated from Streptomyces.
CAS:
93301-58-7
Formula:
C16H24N6O9S
Molecular Weight:
476.46
Purity:
0.98
SMILES:
Cn(/C(ccn1[C@H]2[C@H](O)[C@@H](O)[C@@H]([C@@H](O)[C@@H](NC([C@@H](N)CO)=O)C(O)=O)S2)=N/C(N)=O)c1=O
References
1. Kim JY, Carlson BA, Xu XM, Zeng Y, Chen S, Gladyshev VN, Lee BJ, Hatfield DL. Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA. Biochem Biophys Res Commun. 2011 Jun 17;409(4):814-9. doi: 10.1016/j.bbrc.2011.05.096. Epub 2011 May 23. PubMed PMID: 21624347; PubMed Central PMCID: PMC3124823.
2. Zeng Y, Roy H, Patil PB, Ibba M, Chen S. Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974. Antimicrob Agents Chemother. 2009 Nov;53(11):4619-27. doi: 10.1128/AAC.00782-09. Epub 2009 Aug 31. PubMed PMID: 19721072; PubMed Central PMCID: PMC2772349.
3. Stefanska AL, Fulston M, Houge-Frydrych CS, Jones JJ, Warr SR. A potent seryl tRNA synthetase inhibitor SB-217452 isolated from a Streptomyces species. J Antibiot (Tokyo). 2000 Dec;53(12):1346-53. PubMed PMID: 11217799.