Tagetitoxin
| Code | Size | Price |
|---|
| TAR-T26247-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Tagetitoxin is a chlorosis-inducing phytoxin produced by Pseudomonas syringae pv. tagetis that suppresses RNA synthesis directed by chloroplast RNA polymerase.
CAS:
87913-21-1
Formula:
C11H17N2O11PS
Molecular Weight:
416.29
Purity:
0.98
SMILES:
CC(=O)O[C@@H]1[C@@H](N)[C@@H](OP(O)(O)=O)[C@@]2(CS[C@@](O)([C@H]1O2)C(N)=O)C(O)=O
References
1. Aliev AE, Karu K, Mitchell RE, Porter MJ. The structure of tagetitoxin. Org Biomol Chem. 2016 Jan 7;14(1):238-45. doi: 10.1039/c5ob02076j. Epub 2015 Oct 30. PubMed PMID: 26517805.
2. Yamada H, Adachi M, Nishikawa T. Stereocontrolled synthesis of the oxathiabicyclo[3.3.1]nonane core structure of tagetitoxin. Chem Commun (Camb). 2013 Dec 11;49(95):11221-3. doi: 10.1039/c3cc46949b. Epub 2013 Oct 23. PubMed PMID: 24150697.
3. Yuzenkova Y, Roghanian M, Bochkareva A, Zenkin N. Tagetitoxin inhibits transcription by stabilizing pre-translocated state of the elongation complex. Nucleic Acids Res. 2013 Nov;41(20):9257-65. doi: 10.1093/nar/gkt708. Epub 2013 Aug 9. PubMed PMID: 23935117; PubMed Central PMCID: PMC3814378.
4. Nedialkov YA, Nudler E, Burton ZF. RNA polymerase stalls in a post-translocated register and can hyper-translocate. Transcription. 2012 Sep-Oct;3(5):260-9. doi: 10.4161/trns.22307. Epub 2012 Sep 1. PubMed PMID: 23132506; PubMed Central PMCID: PMC3632624.