Teixobactin
| Code | Size | Price |
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| TAR-T26257-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Teixobactin is a recently described antibiotic . It is a new class produced by a hitherto undescribed soil microorganism (provisionally named Eleftheria terrae).
CAS:
1613225-53-8
Formula:
C58H95N15O15
Molecular Weight:
1242.488
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N([C@@H](CO)C(N)=O)[C@@H]1[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](C[C@H]2CNC(=N)N2)NC(=O)[C@H](C)NC1=O)[C@@H](C)CC
References
1. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. doi: 10.1093/jac/dkv175. Epub 2015 Jun 18. Review. PubMed PMID: 26089440.
2. Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Sch?berle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Erratum in: Nature. 2015 Apr 16;520(7547):388. PubMed PMID: 25561178.
3. Jad YE, Acosta GA, Naicker T, Ramtahal M, El-Faham A, Govender T, Kruger HG, de la Torre BG, Albericio F. Synthesis and Biological Evaluation of a Teixobactin Analogue. Org Lett. 2015 Dec 18;17(24):6182-5. doi: 10.1021/acs.orglett.5b03176. Epub 2015 Dec 10. PubMed PMID: 26654835.
4. Yang H, Chen KH, Nowick JS. Elucidation of the Teixobactin Pharmacophore. ACS Chem Biol. 2016 Jul 15;11(7):1823-6. doi: 10.1021/acschembio.6b00295. Epub 2016 Jun 3. PubMed PMID: 27232661; PubMed Central PMCID: PMC5283680.