TM6008
| Code | Size | Price |
|---|
| TAR-T26281-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26281-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26281-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.
CAS:
945008-17-3
Formula:
C21H17N5O3
Molecular Weight:
387.399
Purity:
0.98
SMILES:
Cn1c(N)c(C(=O)c2cc(nc3ccccc23)-c2ccccn2)c(=O)n(C)c1=O
References
1. Tada Y, Ogawa M, Watanabe R, Zempo H, Takamura C, Suzuki J, Dan T, Miyata T, Isobe M, Komuro I. Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis. Expert Opin Investig Drugs. 2014 Feb;23(2):149-62. doi: 10.1517/13543784.2014.855196. Epub 2013 Nov 11. PubMed PMID: 24205804.
2. Kontani S, Nagata E, Uesugi T, Moriya Y, Fujii N, Miyata T, Takizawa S. A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia. Neurochem Res. 2013 Dec;38(12):2588-94. doi: 10.1007/s11064-013-1175-0. Epub 2013 Oct 17. PubMed PMID: 24132642; PubMed Central PMCID: PMC3898357.
3. Takizawa S, Nagata E, Luo HR. [Novel neuroprotective agents: a HIF activator and an Akt activator]. Rinsho Shinkeigaku. 2012;52(11):911-2. Japanese. PubMed PMID: 23196464.
4. Takeda K, Ichiki T, Narabayashi E, Inanaga K, Miyazaki R, Hashimoto T, Matsuura H, Ikeda J, Miyata T, Sunagawa K. Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2132-7. doi: 10.1161/ATVBAHA.109.196071. Epub 2009 Sep 17. PubMed PMID: 19762779.