ZYJ-34c
| Code | Size | Price |
|---|
| TAR-T26355-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26355-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26355-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi).
CAS:
1314556-93-8
Formula:
C31H42N4O7
Molecular Weight:
582.698
Purity:
0.98
SMILES:
CCC(C)C(NC(=O)CC(C)(C)C)C(=O)N1Cc2cc(OCC(=O)NO)ccc2CC1C(=O)Nc1ccc(OC)cc1
References
1. Yang H, Xu W, Li Y, Lan P, Zhang J, Zhang Y, Zhang C. Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by inducing p21WAF1 expression and cell cycle arrest. Anticancer Drugs. 2014 Aug;25(7):767-77. doi: 10.1097/CAD.0000000000000101. PubMed PMID: 24686006.
2. Zhang Y, Inks ES, Zhu M, Chou CJ, Fang H, Li M, Shen Y, Yi F, Xu W. Discovery of a Pair of Diastereomers as Potent HDACs Inhibitors: Determination of Absolute Configuration, Biological Activity Comparison and Computational Study. RSC Adv. 2013 Nov 21;3(43). doi: 10.1039/C3RA43249A. PubMed PMID: 24273644; PubMed Central PMCID: PMC3836556.
3. Zhang Y, Liu C, Chou CJ, Wang X, Jia Y, Xu W. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem Biol Drug Des. 2013 Aug;82(2):125-30. doi: 10.1111/cbdd.12144. Epub 2013 Jul 1. PubMed PMID: 23581848; PubMed Central PMCID: PMC3723752.
4. Zhang Y, Fang H, Feng J, Jia Y, Wang X, Xu W. Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. J Med Chem. 2011 Aug 11;54(15):5532-9. doi: 10.1021/jm200577a. Epub 2011 Jul 11. PubMed PMID: 21714538.