Napitane Mesylate
| Code | Size | Price |
|---|
| TAR-T26363-5mg | 5mg | £1,010.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26363-50mg | 50mg | £1,982.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26363-100mg | 100mg | £2,560.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Napitane Mesylate is a potent alpha 2-adrenoceptor antagonist. Napitane Mesylate blocks norepinephrine uptake by inhibiting the norepinephrine transporter. Napitane Mesylate also binds to CA transporters in the central nervous system and blocks uptake.
CAS:
149189-73-1
Formula:
C23H29NO5S
Molecular Weight:
431.55
Purity:
0.98
SMILES:
CS(O)(=O)=O.C([C@@H]1CCCc2c3OCOc3ccc12)N1CC[C@@H](C1)c1ccccc1
References
1. Cass WA, Friedemann MN, deBernardis JF, Kerkman DJ, Gerhardt GA. Effects of the putative antidepressant, ABT 200, on the clearance of exogenous norepinephrine in rat cerebellum. Synapse. 1995 Sep;21(1):77-84. PubMed PMID: 8525465.
2. Firestone JA, Marks MJ, Gerhardt GA, Browning MD. ABT-200, a norepinephrine uptake inhibitor, blocks Ca2+ signals in chromaffin cells. Eur J Pharmacol. 1994 Oct 14;269(2):177-82. PubMed PMID: 7851493.
3. Hancock AA, Buckner SA, Giardina WJ, Brune ME, Lee JY, Morse PA, Oheim KW, Stanisic DS, Warner RB, Kerkman DJ, et al. Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine. J Pharmacol Exp Ther. 1995 Mar;272(3):1160-9. PubMed PMID: 7891328.
4. Ferrero JL, Thomas SB, Marsh KC, Rodrigues AD, Uchic JT, Buko AM. Implication of P450-metabolite complex formation in the nonlinear pharmacokinetics and metabolic fate of (+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-nap hthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in dogs. Drug Metab Dispos. 2002 Oct;30(10):1094-101. PubMed PMID: 12228185.