Rebastinib

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TargetMol
Product Code: TAR-T2640
Supplier: TargetMol
CodeSizePrice
TAR-T2640-2mg2mg£103.00
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TAR-T2640-5mg5mg£121.00
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TAR-T2640-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T2640-10mg10mg£148.00
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TAR-T2640-25mg25mg£216.00
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TAR-T2640-50mg50mg£283.00
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TAR-T2640-100mg100mg£389.00
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TAR-T2640-200mg200mg£550.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
DCC-2036 (Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit.
CAS:
1020172-07-9
Formula:
C30H28FN7O3
Molecular Weight:
553.598
Pathway:
Cytoskeletal Signaling; Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
Purity:
0.9984
SMILES:
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1
Target:
Apoptosis; FLT; Bcr-Abl; Src

References

1. Chan WW, et al. Cancer Cell. 2011, 19(4), 556-568.