A68930
Code | Size | Price |
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TAR-T26432-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26432-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26432-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
A 68930 is a dopamine D-1 receptor antagonist. A 68930 inhibits NLRP3 inflammasome activity.
CAS:
130465-45-1
Formula:
C16H17NO3
Molecular Weight:
271.316
Purity:
0.98
SMILES:
NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)c1ccccc1
References
1. Jiang W, Huang Y, He F, Liu J, Li M, Sun T, Ren W, Hou J, Zhu L. Dopamine D1 Receptor Agonist A-68930 Inhibits NLRP3 Inflammasome Activation, Controls Inflammation, and Alleviates Histopathology in a Rat Model of Spinal Cord Injury. Spine (Phila Pa 1976). 2016 Mar;41(6):E330-4. doi: 10.1097/BRS.0000000000001287. PubMed PMID: 26966979.
2. Jiang W, Li M, He F, Bian Z, Liu J, He Q, Wang X, Sun T, Zhu L. Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation and protects rats from spinal cord injury-induced acute lung injury. Spinal Cord. 2016 Nov;54(11):951-956. doi: 10.1038/sc.2016.52. Epub 2016 Apr 12. PubMed PMID: 27067657.
3. Martin YC. The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413. Int J Med Chem. 2011;2011:424535. doi: 10.1155/2011/424535. Epub 2011 Mar 24. Review. PubMed PMID: 25954518; PubMed Central PMCID: PMC4412209.
4. Rasheed N, Ahmad A, Singh N, Singh P, Mishra V, Banu N, Lohani M, Sharma S, Palit G. Differential response of A 68930 and sulpiride in stress-induced gastric ulcers in rats. Eur J Pharmacol. 2010 Sep 15;643(1):121-8. doi: 10.1016/j.ejphar.2010.06.032. Epub 2010 Jun 28. PubMed PMID: 20599913.