A 74273
| Code | Size | Price |
|---|
| TAR-T26439-5mg | 5mg | £1,251.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26439-50mg | 50mg | £2,464.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26439-100mg | 100mg | £3,283.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.
CAS:
130316-95-9
Formula:
C44H74N4O8
Molecular Weight:
787.096
Purity:
0.98
SMILES:
CCCC[C@H](O[C@@H](Cc1ccccc1)C(=O)N1CCC(CC1)OCOC)C(=O)NC(CC1CCCCC1)C(O)CC(C(C)C)C(=O)NCCCN1CCOCC1
References
1. Verburg KM, Polakowski JS, Kovar PJ, Klinghofer V, Barlow JL, Stein HH, Mantei RA, Fung AK, Boyd SA, Baker WR, et al. Effects of high doses of A-74273, a novel nonpeptidic and orally bioavailable renin inhibitor. J Cardiovasc Pharmacol. 1993 Jan;21(1):149-55. PubMed PMID: 7678671.
2. Kleinert HD, Stein HH, Boyd S, Fung AK, Baker WR, Verburg KM, Polakowski JS, Kovar P, Barlow J, Cohen J, et al. Discovery of a well-absorbed, efficacious renin inhibitor, A-74273. Hypertension. 1992 Dec;20(6):768-75. PubMed PMID: 1452292.
3. Frishman WH, Fozailoff A, Lin C, Dike C. Renin inhibition: a new approach to cardiovascular therapy. J Clin Pharmacol. 1994 Sep;34(9):873-80. Review. PubMed PMID: 7983230.
4. Wessale JL, Calzadilla SV, Boyd SA, Baker WR, Stein HH, Kovar PJ, Barlow J, Klinghofer V, Mantei R, Kleinert HD. Cardiovascular effects and hemodynamic mechanism of action of the novel, nonpeptidic renin inhibitor A-74273 in dogs. J Cardiovasc Pharmacol. 1993 Oct;22(4):644-52. PubMed PMID: 7505369.