A 74932
| Code | Size | Price |
|---|
| TAR-T26441-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26441-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26441-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
A 74932 is a quinolone antibacterial agent and inhibitor of topoisomerase II enzyme. A-74932 possesses good activity in vivo against both systemic tumour, subcutaneously implanted murine solid tumours and human tumour xenografts.
CAS:
148201-60-9
Formula:
C25H26ClFN4O5
Molecular Weight:
516.95
Purity:
0.98
SMILES:
Cl.CCC[C@@H](N)C(=O)N[C@@H]1CCCN1c1c(F)cc2c3c1oc1ccccc1n3cc(C(O)=O)c2=O
References
1. Chu DT, Hallas R, Clement JJ, Alder J, McDonald E, Plattner JJ. Synthesis and antitumour activities of quinolone antineoplastic agents. Drugs Exp Clin Res. 1992;18(7):275-82. PubMed PMID: 1338309.
2. Snyder RD. Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ Mol Mutagen. 2000;35(1):13-21. PubMed PMID: 10692223.
3. Chu DT, Hallas R, Tanaka SK, Alder J, Balli D, Plattner JJ. Synthesis and antitumour activities of tetracyclic quinolone antineoplastic agents. Drugs Exp Clin Res. 1994;20(5):177-83. PubMed PMID: 7875053.
4. Permana PA, Snapka RM, Shen LL, Chu DT, Clement JJ, Plattner JJ. Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors. Biochemistry. 1994 Sep 20;33(37):11333-9. PubMed PMID: 7727384.