A 80b
| Code | Size | Price |
|---|
| TAR-T26452-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca(2+)-induced contraction. Hypotensive and antihypertensive effect of A-80b possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.
CAS:
135561-94-3
Formula:
C16H17N7
Molecular Weight:
307.361
Purity:
0.98
SMILES:
CNN=c1[nH]nc(-n2nc(C)cc2C)c2[nH]c3ccccc3c12
References
1. Frechilla D, Bernedo E, Castiella E, Lasheras B, Cenarruzabeitia E, Monge A, Aldana I, Alvarez T, Losa MJ, Font M. Antihypertensive and vasodilator effect of A-80b, a new pyridazino indole derivative. Eur J Pharmacol. 1992 Sep 4 ;219(3):409-14. PubMed PMID: 1425969.