TargetMol

ABP688

Product Code:
 
TAR-T26520
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26520-1mg1mg£102.00
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TAR-T26520-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-T26520-5mg5mg£142.00
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TAR-T26520-10mg10mg£189.00
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TAR-T26520-25mg25mg£322.00
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TAR-T26520-50mg50mg£466.00
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Quantity:
TAR-T26520-100mg100mg£647.00
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Further Information

Bioactivity:
ABP688 is a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype (mGluR5). [11C]-ABP688 may be used for imaging purposes using PET.
CAS:
1224977-89-2
Formula:
C15H16N2O
Molecular Weight:
240.306
Pathway:
Neuroscience
Purity:
0.98
SMILES:
CON=C1/CCCC(=C1)C#Cc1cccc(C)n1
Target:
GluR

References

1. DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. In vivo ketamine-induced changes in [??C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biol Psychiatry. 2015 Feb 1;77(3):266-275. doi: 10.1016/j.biopsych.2014.06.024. Epub 2014 Jul 10. PubMed PMID: 25156701; PubMed Central PMCID: PMC4277907. 2. DeLorenzo C, Sovago J, Gardus J, Xu J, Yang J, Behrje R, Kumar JS, Devanand DP, Pelton GH, Mathis CA, Mason NS, Gomez-Mancilla B, Aizenstein H, Mann JJ, Parsey RV. Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [??C]ABP688. Transl Psychiatry. 2015 Dec 8;5:e693. doi: 10.1038/tp.2015.189. PubMed PMID: 26645628; PubMed Central PMCID: PMC5068588. 3. Kawamura K, Yamasaki T, Kumata K, Furutsuka K, Takei M, Wakizaka H, Fujinaga M, Kariya K, Yui J, Hatori A, Xie L, Shimoda Y, Hashimoto H, Hayashi K, Zhang MR. Binding potential of (E)-[??C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its ??C-labelled Z-isomer. Nucl Med Biol. 2014 Jan;41(1):17-23. doi: 10.1016/j.nucmedbio.2013.09.008. Epub 2013 Oct 8. PubMed PMID: 24183615. 4. DuBois JM, Rousset OG, Rowley J, Porras-Betancourt M, Reader AJ, Labbe A, Massarweh G, Soucy JP, Rosa-Neto P, Kobayashi E. Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET. Eur J Nucl Med Mol Imaging. 2016 Jan;43(1):152-62. doi: 10.1007/s00259-015-3167-6. Epub 2015 Aug 21. PubMed PMID: 26290423.