Acanthoic acid
| Code | Size | Price |
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| TAR-T26545-5mg | 5mg | £3,685.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits inflammatory cytokines by stopping IL-1β, IL-6 and TNF-α production and NF-κB activation in LPS-stimulated alveolar macrophages.
CAS:
119290-87-8
Formula:
C20H30O2
Molecular Weight:
302.458
Purity:
0.98
SMILES:
[H][C@@]12CC[C@]3([H])[C@@](C)(CCC[C@@]3(C)C1=CC[C@@](C)(C2)C=C)C(O)=O
References
1. Qiushi W, Guanghua L, Guangquan X. Acanthoic acid ameliorates lipopolysaccharide-induced acute lung injury. Eur J Pharmacol. 2015 Mar 5;750:32-8. doi: 10.1016/j.ejphar.2015.01.023. Epub 2015 Jan 23. PubMed PMID: 25620130.
2. Wei C, Tan CK, Xiaoping H, Junqiang J. Acanthoic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts. Inflammation. 2015 Apr;38(2):896-901. doi: 10.1007/s10753-014-0051-7. PubMed PMID: 25373915.
3. Bai T, Yao YL, Jin XJ, Lian LH, Li Q, Yang N, Jin Q, Wu YL, Nan JX. Acanthoic acid, a diterpene in Acanthopanax koreanum, ameliorates the development of liver fibrosis via LXRs signals. Chem Biol Interact. 2014 Jul 25;218:63-70. doi: 10.1016/j.cbi.2014.04.016. Epub 2014 May 5. PubMed PMID: 24802811.
4. Trav?s PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Mart?n-Sanz P, Palladino MA, Bosc? L. Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110?/? subunits and inhibition of NF-?B. Chem Biol. 2014 Aug 14;21(8):955-66. doi: 10.1016/j.chembiol.2014.06.005. Epub 2014 Jul 24. PubMed PMID: 25065531.