AzddMeC
| Code | Size | Price |
|---|
| TAR-T26726-50mg | 50mg | £804.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26726-100mg | 100mg | £1,267.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Az-Dcme, a RNA-directed DNA polymerase inhibitor, is used potentially for the treatment of HIV infection.
CAS:
87190-79-2
Formula:
C10H14N6O3
Molecular Weight:
266.261
Purity:
0.98
SMILES:
Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)nc1N
References
1. Schinazi RF, Schlueter-Wirtz S, Stuyver L. Early detection of mixed mutations selected by antiretroviral agents in HIV-infected primary human lymphocytes. Antivir Chem Chemother. 2001;12 Suppl 1:61-5. PubMed PMID: 11594690.
2. Boudinot FD, Schinazi RF, Doshi KJ, McClure HM, Chu CK. Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys. Drug Metab Dispos. 1993 Sep-Oct;21(5):855-60. PubMed PMID: 7902248.
3. Cretton EM, Xie MY, Goudgaon NM, Schinazi RF, Chu CK, Sommadossi JP. Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides. Biochem Pharmacol. 1992 Sep 1;44(5):973-80. PubMed PMID: 1326966.
4. Matthes E, Reimer K, von Janta-Lipinski M, Meisel H, Lehmann C. Comparative inhibition of hepatitis B virus DNA polymerase and cellular DNA polymerases by triphosphates of sugar-modified 5-methyldeoxycytidines and of other nucleoside analogs. Antimicrob Agents Chemother. 1991 Jun;35(6):1254-7. PubMed PMID: 1929276; PubMed Central PMCID: PMC284326.