Bibw 22
| Code | Size | Price |
|---|
| TAR-T26803-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26803-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26803-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Bibw 22 is a bifunctional modulator of P-glycoprotein and nucleoside transport.
CAS:
137694-16-7
Formula:
C30H43N7O4
Molecular Weight:
565.719
Purity:
0.98
SMILES:
C[C@H]1CN(C[C@@H](C)O1)c1nc(N(CCO)CC(C)(C)O)c2nc(-c3ccccc3)c(nc2n1)N1C[C@H](C)O[C@H](C)C1
References
1. Chen HX, Bamberger U, Heckel A, Guo X, Cheng YC. BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport. Cancer Res. 1993 May 1;53(9):1974-7. PubMed PMID: 8097671.
2. Dieckmann-Schuppert A, Bamberger U, Schwarz RT. Chloroquine resistance in Plasmodium falciparum is not reversed by BIBW-22, a compound reversing the multidrug resistance phenotype in mammalian cancer cells. Biochem Pharmacol. 1993 Oct 19;46(8):1421-4. PubMed PMID: 8240391.
3. Jansen WJ, Pinedo HM, Kuiper CM, Lincke C, Bamberger U, Heckel A, Boven E. Biochemical modulation of 'classical' multidrug resistance by BIBW22BS, a potent derivative of dipyridamole. Ann Oncol. 1994 Oct;5(8):733-9. PubMed PMID: 7826906.
4. Liu Z, Lheureux F, Pouliot JF, Heckel A, Bamberger U, Georges E. BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Mol Pharmacol. 1996 Sep;50(3):482-92. PubMed PMID: 8794885.