BILB-1941

TargetMol
Product Code: TAR-T26815
Supplier: TargetMol
CodeSizePrice
TAR-T26815-1mg1mg£335.00
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TAR-T26815-5mg5mg£711.00
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TAR-T26815-10mg10mg£946.00
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TAR-T26815-1mL1 mL * 10 mM (in DMSO)£1,002.00
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TAR-T26815-25mg25mg£1,396.00
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TAR-T26815-50mg50mg£1,862.00
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TAR-T26815-100mg100mg£2,424.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1

Further Information

Bioactivity:
BILB-1941 is a HCV NS5B polymerase inhibitor potentially for the treatment of HCV infection.
CAS:
494856-61-0
Formula:
C34H34N4O4
Molecular Weight:
562.67
Pathway:
Proteases/Proteasome|Microbiology/Virology
Purity:
0.98
SMILES:
Cn1c(c(C2CCCC2)c2ccc(cc12)C(=O)NC1(CCC1)C(=O)Nc1ccc(C=CC(O)=O)cc1)-c1ccccn1
Target:
HCV Protease

References

1. Beaulieu PL, Anderson PC, Bethell R, B?s M, Bousquet Y, Brochu C, Cordingley MG, Fazal G, Garneau M, Gillard JR, Kawai S, Marquis M, McKercher G, Poupart MA, Stammers T, Thavonekham B, Wernic D, Duan J, Kukolj G. Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection. J Med Chem. 2014 Dec 11;57(23):10130-43. doi: 10.1021/jm501532z. PubMed PMID: 25393851. 2. Beaulieu PL, B?s M, Cordingley MG, Chabot C, Fazal G, Garneau M, Gillard JR, Jolicoeur E, LaPlante S, McKercher G, Poirier M, Poupart MA, Tsantrizos YS, Duan J, Kukolj G. Discovery of the first thumb pocket 1 NS5B polymerase inhibitor (BILB 1941) with demonstrated antiviral activity in patients chronically infected with genotype 1 hepatitis C virus (HCV). J Med Chem. 2012 Sep 13;55(17):7650-66. doi: 10.1021/jm3006788. PubMed PMID: 22849725. 3. Erhardt A, Deterding K, Benhamou Y, Reiser M, Forns X, Pol S, Calleja JL, Ross S, Spangenberg HC, Garcia-Samaniego J, Fuchs M, Enr?quez J, Wiegand J, Stern J, Wu K, Kukolj G, Marquis M, Beaulieu P, Nehmiz G, Steffgen J; BILB 1941 Study Group.. Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment. Antivir Ther. 2009;14(1):23-32. PubMed PMID: 19320234.