Bisindolylmaleimide I HCl
| Code | Size | Price |
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| TAR-T26826-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T26826-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Bisindolylmaleimide I HCl is a specific ATP-competitive PKC inhibitor.
CAS:
176504-36-2
Formula:
C25H25ClN4O2
Molecular Weight:
448.95
Purity:
0.98
SMILES:
Cl.CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
References
1. Girardi BA, Ribeiro DA, Signor C, Muller M, Gais MA, Mello CF, Rubin MA. Spermidine-induced improvement of reconsolidation of memory involves calcium-dependent protein kinase in rats. Learn Mem. 2015 Dec 15;23(1):21-8. doi: 10.1101/lm.039396.115. Print 2016 Jan. PubMed PMID: 26670183; PubMed Central PMCID: PMC4749837.
2. Wang W, Song N, Zhang H, Xie J, Wang J. 6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line. Int J Biochem Cell Biol. 2012 Nov;44(11):1987-92. doi: 10.1016/j.biocel.2012.07.018. Epub 2012 Jul 27. PubMed PMID: 22846799.
3. Guerra GP, Mello CF, Bochi GV, Pazini AM, Rosa MM, Ferreira J, Rubin MA. Spermidine-induced improvement of memory involves a cross-talk between protein kinases C and A. J Neurochem. 2012 Jul;122(2):363-73. doi: 10.1111/j.1471-4159.2012.07778.x. Epub 2012 May 24. PubMed PMID: 22564082.
4. McBane JE, Santerre JP, Labow R. Effect of phorbol esters on the macrophage-mediated biodegradation of polyurethanes via protein kinase C activation and other pathways. J Biomater Sci Polym Ed. 2009;20(4):437-53. doi: 10.1163/156856209X416467. PubMed PMID: 19228446.