CCT036477
Code | Size | Price |
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TAR-T26968-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26968-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26968-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
CCT036477 is a selective inhibitor of wingless-type MMTV integration site family dependent transcription. CCT036477reduces the transcriptional activity of the T-cell factor and lymphoid enhancer factor transcription factor family at the ?-catenin level.
CAS:
305372-78-5
Formula:
C21H18ClN3
Molecular Weight:
347.85
Purity:
0.98
SMILES:
Cc1[nH]c2ccccc2c1C(Nc1ccccn1)c1ccc(Cl)cc1
References
1. Barghout SH, Zepeda N, Xu Z, Steed H, Lee CH, Fu Y. Elevated ?-catenin activity contributes to carboplatin resistance in A2780cp ovarian cancer cells. Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):173-8. doi: 10.1016/j.bbrc.2015.10.138. Epub 2015 Oct 29. PubMed PMID: 26522223.
2. Mathur R, Sehgal L, Braun FK, Berkova Z, Romaguerra J, Wang M, Rodriguez MA, Fayad L, Neelapu SS, Samaniego F. Targeting Wnt pathway in mantle cell lymphoma-initiating cells. J Hematol Oncol. 2015 Jun 6;8:63. doi: 10.1186/s13045-015-0161-1. PubMed PMID: 26048374; PubMed Central PMCID: PMC4460883.
3. Jard? T, Evans RJ, McQuillan KL, Parry L, Feng GJ, Alvares B, Clarke AR, Dale TC. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-O?N89?-catenin system. Oncogene. 2013 Feb 14;32(7):883-93. doi: 10.1038/onc.2012.103. Epub 2012 Apr 2. PubMed PMID: 22469981; PubMed Central PMCID: PMC3389516.