CK59
| Code | Size | Price |
|---|
| TAR-T27032-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27032-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27032-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CK59 is a reversible inhibitor of calcium-calmodulin-dependent kinase II (CaMKII). CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50 μM, which is only five fold larger than the reported IC50 values for CaMKII inhibition.
CAS:
926319-75-7
Formula:
C21H37N7O3
Molecular Weight:
435.573
Purity:
0.98
SMILES:
CC(C)n1cnc2c(NCCCCCCNC(=O)OC(C)(C)C)nc(NCCO)nc12
References
1. Wei Y, Han C, Wang Y, Wu B, Su T, Liu Y, He R. Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII. Aging Cell. 2015 Oct;14(5):754-63. doi: 10.1111/acel.12355. Epub 2015 Jun 11. PubMed PMID: 26095350; PubMed Central PMCID: PMC4568963.
2. Jiang L, Xu L, Song Y, Li J, Mao J, Zhao AZ, He W, Yang J, Dai C. Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/?-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria. J Biol Chem. 2013 Aug 9;288(32):23368-79. doi: 10.1074/jbc.M113.460394. Epub 2013 Jun 26. PubMed PMID: 23803607; PubMed Central PMCID: PMC3743506.
3. Karls AS, Mynlieff M. Nonspecific, reversible inhibition of voltage-gated calcium channels by CaMKII inhibitor CK59. Cell Mol Neurobiol. 2013 Jul;33(5):723-9. doi: 10.1007/s10571-013-9941-8. Epub 2013 May 9. PubMed PMID: 23657616; PubMed Central PMCID: PMC3693846.
4. Scheiter M, Bulitta B, van Ham M, Klawonn F, K?nig S, J?nsch L. Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions. Front Immunol. 2013 Mar 18;4:66. doi: 10.3389/fimmu.2013.00066. eCollection 2013. PubMed PMID: 23508354; PubMed Central PMCID: PMC3600540.