SL327
Code | Size | Price |
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TAR-T2708-5mg | 5mg | £113.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2708-10mg | 10mg | £142.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2708-50mg | 50mg | £308.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
CAS:
305350-87-2
Formula:
C16H12F3N3S
Molecular Weight:
335.35
Pathway:
DNA Damage/DNA Repair; MAPK; Cell Cycle/Checkpoint
Purity:
0.9974
SMILES:
NC(Sc1ccc(N)cc1)=C(C#N)c1ccccc1C(F)(F)F
Target:
MEK; DNA/RNA Synthesis
References
1. Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.
2. Atkins CM, et al. Nat Neurosci, 1998, 1(7), 602-609.
3. Selcher JC, et al. Learn Mem, 1999, 6(5), 478-490.
4. Valjent E, J Neurosci, 2000, 20(23), 8701-8709.