Delucemine Hydrochloride
| Code | Size | Price |
|---|
| TAR-T27143-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27143-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27143-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Delucemine Hydrochloride is a glutamate receptor antagonist with moderate affinity. Delucemine Hydrochloride inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells and displaces the binding of [3H]MK-801 to rat cortical membranes. Delucemine Hydrochloride improved measures of brain tissue edema and ion homeostasis.
CAS:
186495-99-8
Formula:
C16H18ClF2N
Molecular Weight:
297.77
Purity:
0.98
SMILES:
Cl.CNCCC(c1cccc(F)c1)c1cccc(F)c1
References
1. Browne KD, Leoni MJ, Iwata A, Chen XH, Smith DH. Acute treatment with MgSO4 attenuates long-term hippocampal tissue loss after brain trauma in the rat. J Neurosci Res. 2004 Sep 15;77(6):878-83. PubMed PMID: 15334605.
2. Fuchigami T, Haradahira T, Arai T, Okauchi T, Maeda J, Suzuki K, Yamamoto F, Suhara T, Sasaki S, Maeda M. Synthesis and brain regional distribution of [11C]NPS 1506 in mice and rat: an N-methyl-D-aspartate (NMDA) receptor antagonist. Biol Pharm Bull. 2003 Nov;26(11):1570-3. PubMed PMID: 14600403.
3. Lorber A, Artru AA, Lam MA, Mueller LA, Karpas Z, Roytblat L, Shapira Y. NPS 1506: a novel NMDA receptor antagonist: neuroprotective effects in a model of closed head trauma in rats. J Neurosurg Anesthesiol. 2000 Oct;12(4):345-55. PubMed PMID: 11147383.
4. Leoni MJ, Chen XH, Mueller AL, Cheney J, McIntosh TK, Smith DH. NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat. Exp Neurol. 2000 Dec;166(2):442-9. PubMed PMID: 11085909.