Deoxynybomycin
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| TAR-T27147-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Deoxynybomycin, a selective anti-tumor agent, inhibits topoisomerase I and induces apoptosis.
CAS:
27259-98-9
Formula:
C16H14N2O3
Molecular Weight:
282.299
Purity:
0.98
SMILES:
Cc1cc(=O)n2COc3c2c1cc1c(C)cc(=O)n(C)c31
References
1. Richter MF, Drown BS, Riley AP, Garcia A, Shirai T, Svec RL, Hergenrother PJ. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature. 2017 May 10. doi: 10.1038/nature22308. [Epub ahead of print] PubMed PMID: 28489819.
2. Parkinson EI, Bair JS, Nakamura BA, Lee HY, Kuttab HI, Southgate EH, Lezmi S, Lau GW, Hergenrother PJ. Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria. Nat Commun. 2015 Apr 24;6:6947. doi: 10.1038/ncomms7947. PubMed PMID: 25907309; PubMed Central PMCID: PMC4421842.
3. Egawa K, Yamori T, Nosaka C, Kunimoto S, Takeuchi T, Nos K. Deoxynybomycin is a selective anti-tumor agent inducing apoptosis and inhibiting topoisomerase I. Biol Pharm Bull. 2000 Sep;23(9):1036-40. PubMed PMID: 10993200.
4. Pope JA Jr, Nelson RA, Schaffner CP, Rosen RT, Pandey RC. Applications of thin layer chromatography, high performance liquid chromatography and mass spectrometry in the fermentation and isolation of the antibiotic nybomycin. J Ind Microbiol. 1990 Sep;6(1):61-9. PubMed PMID: 1369285.