DL-threo dihydrosphingosine
| Code | Size | Price |
|---|
| TAR-T27189-5mg | 5mg | £1,010.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27189-50mg | 50mg | £1,982.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27189-100mg | 100mg | £2,560.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo dihydrosphingosine may be usefully employed to block smooth muscle cell proliferation.
CAS:
2304-75-8
Formula:
C18H39NO2
Molecular Weight:
301.515
Purity:
0.98
SMILES:
CCCCCCCCCCCCCCC[C@@H](O)[C@H](N)CO
References
1. Tolan D, Conway AM, Steele L, Pyne S, Pyne NJ. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br J Pharmacol. 1996 Sep;119(2):185-6. PubMed PMID: 8886394; PubMed Central PMCID: PMC1915874.
2. Meyer SG, de Groot H. Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling. Biochim Biophys Acta. 2003 Dec 7;1643(1-3):1-4. PubMed PMID: 14654222.
3. Ma Y, She X, Yang S. Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (H?O?) levels in guard cells in Vicia faba. Sci China Life Sci. 2012 Nov;55(11):974-83. doi: 10.1007/s11427-012-4386-8. Epub 2012 Oct 22. PubMed PMID: 23090064.
4. Buehrer BM, Bell RM. Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways. J Biol Chem. 1992 Feb 15;267(5):3154-9. PubMed PMID: 1310683.