D-Mannuronic Acid
| Code | Size | Price |
|---|
| TAR-T27191-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27191-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27191-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB.
CAS:
6906-37-2
Formula:
C6H10O7
Molecular Weight:
194.139
Purity:
0.98
SMILES:
OC1O[C@@H]([C@@H](O)[C@H](O)[C@@H]1O)C(O)=O
References
1. Vojdanian M, Ahmadi H, Jamshidi AR, Mahmoudi M, Gharibdoost F, Barati A, Mirshafiey A. The anti-migraine effects of M2000 (?-D-mannuronic acid) on a patient with rheumatoid arthritis; as a case report. Curr Clin Pharmacol. 2017 Jun 4. doi: 10.2174/1574884712666170605101845. [Epub ahead of print] PubMed PMID: 28578645.
2. Sanka I, Suyono EA, Alam P. The effects of diatom pore-size on the structures and extensibilities of single mucilage molecules. Carbohydr Res. 2017 May 26;448:35-42. doi: 10.1016/j.carres.2017.05.014. [Epub ahead of print] PubMed PMID: 28578200.
3. Barati A, Jamshidi AR, Ahmadi H, Aghazadeh Z, Mirshafiey A. Effects of ?-d-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, ROR?t, IL4 and GATA3 gene expressions in rheumatoid arthritis patients. Drug Des Devel Ther. 2017 Mar 30;11:1027-1033. doi: 10.2147/DDDT.S129419. eCollection 2017. PubMed PMID: 28408801; PubMed Central PMCID: PMC5384716.
4. Stewart MB, Myat DT, Kuiper M, Manning RJ, Gray SR, Orbell JD. A structural basis for the amphiphilic character of alginates - Implications for membrane fouling. Carbohydr Polym. 2017 May 15;164:162-169. doi: 10.1016/j.carbpol.2017.01.072. Epub 2017 Jan 22. PubMed PMID: 28325313.