TargetMol

DPI 201-106

Product Code:
 
TAR-T27205
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27205-5mg5mg£108.00
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TAR-T27205-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T27205-10mg10mg£135.00
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TAR-T27205-25mg25mg£201.00
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TAR-T27205-50mg50mg£269.00
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  • Further Information
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Further Information

Bioactivity:
DPI 201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation resulting in a positive inotropic effect. DPI-201-106 also inhibits the inward and delayed rectifier potassium currents and L-type calcium current.
CAS:
97730-95-5
Formula:
C29H30N4O2
Molecular Weight:
466.585
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
OC(COc1cccc2[nH]c(cc12)C#N)CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Target:
Sodium Channel

References

1. Cheng HC, Incardona J. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):174-84. 2. G Scholtysik, et al. Interaction of DPI 201-106 with cardiac glycosides. J Cardiovasc Pharmacol. 1989 Feb;13(2):342-7. 3. M Mevissen, et al. Identification of a cardiac sodium channel insensitive to synthetic modulators. J Cardiovasc Pharmacol Ther. 2001 Apr;6(2):201-12. 4. G Scholtysik, et al. DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties. Naunyn Schmiedebergs Arch Pharmacol.1985 May;329(3):316-25.