DS-8587
| Code | Size | Price |
|---|
| TAR-T27211-5mg | 5mg | £2,376.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27211-50mg | 50mg | £4,713.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27211-100mg | 100mg | £6,657.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
DS-8587 is a DNA topoisomerase inhibitor. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. DS-8587 significantly reduces the number of viable bacteria in a murine model of F. necrophorum-induced liver abscess. In the presence of the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, no significant changes were observed in the MIC for DS-8587.
CAS:
1356918-39-2
Formula:
C21H27ClF3N3O5
Molecular Weight:
493.91
Purity:
0.98
SMILES:
O.O.Cl.Cc1c(N2C[C@]3(N)CCC[C@]3(F)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)[C@@H]1C[C@@H]1F
References
1. Nagaoka K, Yanagihara K, Morinaga Y, Kurosaka Y, Hoshino K, Kohno S. In vivo antianaerobe activity of DS-8587, a new fluoroquinolone, against Fusobacterium necrophorum in a mouse model. J Infect Chemother. 2017 Mar;23(3):131-135. doi: 10.1016/j.jiac.2016.09.007. PubMed PMID: 28109739.
2. Higuchi S, Shikata M, Chiba M, Hoshino K, Gotoh N. Characteristics of antibiotic resistance and sequence type of Acinetobacter baumannii clinical isolates in Japan and the antibacterial activity of DS-8587. J Infect Chemother. 2014 Apr;20(4):256-61. doi: 10.1016/j.jiac.2013.12.001. PubMed PMID: 24709045.
3. Higuchi S, Kurosaka Y, Uoyama S, Yoshida K, Chiba M, Ishii C, Fujikawa K, Karibe Y, Hoshino K. Anti-multidrug-resistant Acinetobacter baumannii activity of DS-8587: In vitro activity and in vivo efficacy in a murine calf muscle infection model. J Infect Chemother. 2014 May;20(5):312-6. doi: 10.1016/j.jiac.2014.01.011. PubMed PMID: 24594453.
4. Higuchi S, Onodera Y, Chiba M, Hoshino K, Gotoh N. Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii. Antimicrob Agents Chemother. 2013 Apr;57(4):1978-81. doi: 10.1128/AAC.02374-12. PubMed PMID: 23380726; PubMed Central PMCID: PMC3623304.