Dunnione
| Code | Size | Price |
|---|
| TAR-T27218-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27218-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27218-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Dunnione is an antifungal agent exerting its action primarily through initiation of redox cycling.
CAS:
33404-57-8
Formula:
C15H14O3
Molecular Weight:
242.274
Purity:
0.98
SMILES:
CC1OC2=C(C(=O)C(=O)c3ccccc23)C1(C)C
References
1. Bian J, Xu L, Deng B, Qian X, Fan J, Yang X, Liu F, Xu X, Guo X, Li X, Sun H, You Q, Zhang X. Synthesis and evaluation of (?)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1). Bioorg Med Chem Lett. 2015 Mar 15;25(6):1244-8. doi: 10.1016/j.bmcl.2015.01.057. Epub 2015 Jan 31. PubMed PMID: 25677663.
2. Park D, Jo IG, Jang JY, Kwak TH, Yoo SK, Jeon JH, Choi EK, Joo SS, Kim O, Kim YB. A Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis. Biomol Ther (Seoul). 2015 Sep;23(5):449-57. doi: 10.4062/biomolther.2015.034. Epub 2015 Sep 1. PubMed PMID: 26336585; PubMed Central PMCID: PMC4556205.
3. Jo IG, Park D, Kyung J, Kim D, Cai J, Kim J, Kwak TH, Yoo SK, Jeong HS, Kim YB. Inhibitory effects of a ?-dunnione compound MB12662 on gastric secretion and ulcers. Lab Anim Res. 2013 Sep;29(3):178-81. doi: 10.5625/lar.2013.29.3.178. Epub 2013 Sep 27. PubMed PMID: 24106514; PubMed Central PMCID: PMC3791353.
4. Pandit A, Kim HJ, Oh GS, Shen A, Lee SB, Khadka D, Lee S, Shim H, Yang SH, Cho EY, Kwon KB, Kwak TH, Choe SK, Park R, So HS. Dunnione ameliorates cisplatin-induced small intestinal damage by modulating NAD(+) metabolism. Biochem Biophys Res Commun. 2015 Nov 27;467(4):697-703. doi: 10.1016/j.bbrc.2015.10.081. Epub 2015 Oct 21. PubMed PMID: 26498527.