Emicoron
| Code | Size | Price |
|---|
| TAR-T27258-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.
CAS:
1422423-23-1
Formula:
C52H58N6O4
Molecular Weight:
831.074
Purity:
0.98
SMILES:
O=c1n(CCN2CCCCC2)c(=O)c2cc3cc(CCN4CCCCC4)c4cc5c6c(cc(N7CCCCC7)c7c8ccc1c2c8c3c4c67)c(=O)n(CCN1CCCCC1)c5=O
References
1. Porru M, Artuso S, Salvati E, Bianco A, Franceschin M, Diodoro MG, Passeri D, Orlandi A, Savorani F, D'Incalci M, Biroccio A, Leonetti C. Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer. Mol Cancer Ther. 2015 Nov;14(11):2541-51. doi: 10.1158/1535-7163.MCT-15-0253. Epub 2015 Aug 24. PubMed PMID: 26304235.
2. Porru M, Zizza P, Franceschin M, Leonetti C, Biroccio A. EMICORON: A multi-targeting G4 ligand with a promising preclinical profile. Biochim Biophys Acta. 2016 Nov 9. pii: S0304-4165(16)30413-5. doi: 10.1016/j.bbagen.2016.11.010. [Epub ahead of print] PubMed PMID: 27838395.
3. Franceschin M, Rizzo A, Casagrande V, Salvati E, Alvino A, Altieri A, Ciammaichella A, Iachettini S, Leonetti C, Ortaggi G, Porru M, Bianco A, Biroccio A. Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells. ChemMedChem. 2012 Dec;7(12):2144-54. doi: 10.1002/cmdc.201200348. Epub 2012 Oct 24. PubMed PMID: 23097341.
4. Micheli E, Altieri A, Cianni L, Cingolani C, Iachettini S, Bianco A, Leonetti C, Cacchione S, Biroccio A, Franceschin M, Rizzo A. Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells. Biochimie. 2016 Jun;125:223-31. doi: 10.1016/j.biochi.2016.04.008. Epub 2016 Apr 13. PubMed PMID: 27086081.