Fascaplysin chloride
| Code | Size | Price |
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| TAR-T27305-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.
CAS:
114719-57-2
Formula:
C18H11ClN2O
Molecular Weight:
306.75
Purity:
0.98
SMILES:
[Cl-].O=C1c2ccccc2-[n+]2ccc3c([nH]c4ccccc34)c12
References
1. Mischitelli M, Jema? M, Almasry M, Faggio C, Lang F. Triggering of Suicidal Erythrocyte Death by Fascaplysin. Cell Physiol Biochem. 2016;39(4):1638-47. doi: 10.1159/000447865. PubMed PMID: 27626793.
2. Manda S, Sharma S, Wani A, Joshi P, Kumar V, Guru SK, Bharate SS, Bhushan S, Vishwakarma RA, Kumar A, Bharate SB. Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. Eur J Med Chem. 2016 Jan 1;107:1-11. doi: 10.1016/j.ejmech.2015.10.049. PubMed PMID: 26560048.
3. Ampofo E, Sp?ter T, M?ller I, Eichler H, Menger MD, Laschke MW. The Marine-Derived Kinase Inhibitor Fascaplysin Exerts Anti-Thrombotic Activity. Mar Drugs. 2015 Nov 9;13(11):6774-91. doi: 10.3390/md13116774. PubMed PMID: 26569265; PubMed Central PMCID: PMC4663553.
4. Mahgoub T, Eustace AJ, Collins DM, Walsh N, O'Donovan N, Crown J. Kinase inhibitor screening identifies CDK4 as a potential therapeutic target for melanoma. Int J Oncol. 2015 Sep;47(3):900-8. doi: 10.3892/ijo.2015.3097. PubMed PMID: 26201960; PubMed Central PMCID: PMC4532220.