Fengabine
Code | Size | Price |
---|
TAR-T27310-1mg | 1mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27310-5mg | 5mg | £213.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27310-10mg | 10mg | £279.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27310-25mg | 25mg | £477.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27310-50mg | 50mg | £625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27310-100mg | 100mg | £859.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27310-500mg | 500mg | £1,653.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Fengabine is GABA receptor agonist. Its antidepressant effects are reversed by GABAA receptor antagonists like bicuculline and it has hence been labeled as GABAergic; however, it does not actually bind to GABA receptors, nor does it inhibit GABA-T. In clinical trials, fengabine's efficacy was comparable to that of the tricyclic antidepressants, but with a more rapid onset of action and much less side effects. Notably, fengabine lacks any sedative effects.
CAS:
80018-06-0
Formula:
C17H17Cl2NO
Molecular Weight:
322.23
Pathway:
Membrane transporter/Ion channel|Neuroscience
Purity:
0.98
SMILES:
CCCCN=C(c1ccccc1Cl)c1cc(Cl)ccc1O
Target:
GABA Receptor
References
1. Fairweather DB, Kerr JS, Hilton S, Hindmarch I. A placebo controlled double-blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers. Br J Clin Pharmacol. 1993 Mar;35(3):278-83. PubMed PMID: 8471403; PubMed Central PMCID: PMC1381575.
2. Pitsiu M, Parker EM, Aarons L, Holt B, Rowland M. A comparison of the relative sensitivities of factor VII and prothrombin time measurements in detecting drug interactions with warfarin. Eur J Clin Pharmacol. 1992;42(6):645-9. PubMed PMID: 1623906.
3. Aley KO, Kulkarni SK. Altered response to GABAergic agents following electro and chemo convulsions in mice. Indian J Exp Biol. 1991 Mar;29(3):241-3. PubMed PMID: 1651904.
4. Nielsen NP, Cesana B, Zizolfi S, Ascalone V, Priore P, Morselli PL. Therapeutic effects of fengabine, a new GABAergic agent, in depressed outpatients: a double-blind study versus clomipramine. Acta Psychiatr Scand. 1990 Nov;82(5):366-71. PubMed PMID: 2281807.