Fostedil
| Code | Size | Price |
|---|
| TAR-T27351-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27351-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27351-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardial blood flow during partial coronary artery occlusion despite a reduction in aortic pressure. In a model of total coronary artery occlusion.
CAS:
75889-62-2
Formula:
C18H20NO3PS
Molecular Weight:
361.4
Purity:
0.98
SMILES:
CCOP(=O)(Cc1ccc(cc1)-c1nc2ccccc2s1)OCC
References
1. Sekine Y, Hirakawa N, Kashiwaba N, Matsumoto H, Kutsuma T, Yamaura T, Sekine A. A novel histamine 2(H2) receptor antagonist with gastroprotective activity. I. Synthesis and pharmacological evaluation of N-phenoxypropylacetamide derivatives with thioether function. Chem Pharm Bull (Tokyo). 1998 Apr;46(4):610-5. PubMed PMID: 9579036.
2. Tchani G, Baziard-Mouysset G, Stigliani JL, Payard M, Bonnafous R, Tisne-Versailles J. Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil. Pharm Acta Helv. 1994 Jan;68(3):173-9. PubMed PMID: 8121926.
3. Rose U. [2-Aryl substituted benzo-anellated 5-ring-heterocycles as potential agents for the cardiovascular system. 2. 1,3-Benzimidazoles]. Pharmazie. 1991 Nov;46(11):775-7. German. PubMed PMID: 1811227.
4. Staudinger R, Knaus HG, Glossmann H. Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140. J Biol Chem. 1991 Jun 15;266(17):10787-95. PubMed PMID: 1645709.