FR900359
| Code | Size | Price |
|---|
| TAR-T27387-5mg | 5mg | £1,204.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
FR900359 is a specific inhibitor of Gq.
CAS:
107530-18-7
Formula:
C49H75N7O15
Molecular Weight:
1002.173
Purity:
0.98
SMILES:
CCC(=O)N[C@@H]([C@H](O)C(C)C)C(=O)O[C@H](C(C)C)[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@H](OC(=O)[C@H]([C@@H](C)OC)N(C)C1=O)C(C)C
References
1. Reher R, Schamari I, Kehraus S, Annala S, Kuschak M, Sch?berle T, Cr?semann M, Carlier A, Eberl L, M?ller CE, Kostenis E, K?nig GM. The endophyte Candidatus Burkholderia crenata of the TCM plant Ardisia crenata produces the selective Gq-inhibitor FR900359. Planta Med. 2016 Dec;81(S 01):S1-S381. PubMed PMID: 27975935.
2. Schrage R, Schmitz AL, Gaffal E, et al. The experimental power of FR900359 to study Gq-regulated biological processes. Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156. PubMed PMID: 26658454; PubMed Central PMCID: PMC4682109.
3. Zaima K, Deguchi J, Matsuno Y, Kaneda T, Hirasawa Y, Morita H. Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery. J Nat Med. 2013 Jan;67(1):196-201. doi: 10.1007/s11418-012-0644-0. PubMed PMID: 22388972.