GSK-1034702
| Code | Size | Price |
|---|
| TAR-T27446-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27446-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27446-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
GSK-1034702 is a selective M(1) receptor allosteric agonist, it may have therapeutic benefits in disorders of impaired learning including Alzheimer's disease.
CAS:
932373-87-0
Formula:
C18H24FN3O2
Molecular Weight:
333.4
Purity:
0.98
SMILES:
c1ccc2c(c1)c(nn(c2=O)C[C@H]3CCCN3CCCCc4ccc(cc4)OCCCN5CCCCCC5)Cc6ccc(cc6)Cl
References
1. Kealey S, Husbands SM, Bennacef I, Gee AD, Passchier J. Palladium-mediated oxidative carbonylation reactions for the synthesis of (11) C-radiolabelled ureas. J Labelled Comp Radiopharm. 2014 Apr;57(4):202-8. doi: 10.1002/jlcr.3151. Epub 2013 Dec 11. PubMed PMID: 24327390.
2. Scarr E. Muscarinic M1 receptor agonists: can they improve cognitive performance? Int J Neuropsychopharmacol. 2013 May;16(4):717-20. doi: 10.1017/S1461145712001113. Epub 2012 Oct 16. PubMed PMID: 23067681.
3. Nathan PJ, Watson J, Lund J, Davies CH, Peters G, Dodds CM, Swirski B, Lawrence P, Bentley GD, O'Neill BV, Robertson J, Watson S, Jones GA, Maruff P, Croft RJ, Laruelle M, Bullmore ET. The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction. Int J Neuropsychopharmacol. 2013 May;16(4):721-31. doi: 10.1017/S1461145712000752. Epub 2012 Aug 29. PubMed PMID: 22932339.
4. Huiban M, Pampols-Maso S, Passchier J. Fully automated synthesis of the M? receptor agonist [??C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system. Appl Radiat Isot. 2011 Oct;69(10):1390-4. doi: 10.1016/j.apradiso.2011.05.007. Epub 2011 May 18. PubMed PMID: 21605979.