GSK2565363C
| Code | Size | Price |
|---|
| TAR-T27464-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
GSK2565363C is a betulin derivative wth antitumor activity.
CAS:
1422355-65-4
Formula:
C48H71ClN2O6
Molecular Weight:
807.55
Purity:
0.98
SMILES:
[H][C@]12CC[C@@]3([H])[C@@]4(C)CCC(OC(=O)CC(C)(C)C(O)=O)C(C)(C)[C@@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@]1(CC(=O)C(C(C)C)=C21)C(=O)CN(CCN(C)C)Cc1ccc(Cl)cc1
References
1. Schwiebs A, Radeke H. Immunopharmacological activity of betulin in inflammation-associated carcinogenesis. Anticancer Agents Med Chem. 2017 Oct 12. doi: 10.2174/1871520617666171012124820. [Epub ahead of print] PubMed PMID: 29022515.
2. Szoka L, Karna E, Hlebowicz-Sarat K, Karaszewski J, Boryczka S, Palka JA. Acetylenic derivative of betulin induces apoptosis in endometrial adenocarcinoma cell line. Biomed Pharmacother. 2017 Nov;95:429-436. doi: 10.1016/j.biopha.2017.08.104. Epub 2017 Sep 12. PubMed PMID: 28863383.
3. Kumar D, Dubey KK. An efficient process for the transformation of betulin to betulinic acid by a strain of Bacillus megaterium. 3 Biotech. 2017 Jul;7(3):157. doi: 10.1007/s13205-017-0759-9. Epub 2017 Jun 16. PubMed PMID: 28623491; PubMed Central PMCID: PMC5473782.
4. Kaps A, Chodurek E, Orchel A, Jaworska-Kik M, B?benek E, Boryczka S, Kasperczyk J. Influence of 28-O-propynoylbetulin on proliferation and apoptosis of melanotic and amelanotic human melanoma cells. Postepy Hig Med Dosw (Online). 2016 Dec 31;70(0):1404-1408. doi: 10.5604/17322693.1227678. PubMed PMID: 28100848.