GW0072
| Code | Size | Price |
|---|
| TAR-T27505-5mg | 5mg | £1,167.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
GW0072 is a partial agonist of PPARγ.
CAS:
321557-86-2
Formula:
C37H46N2O4S
Molecular Weight:
614.85
Purity:
0.98
SMILES:
CCCCCCC[C@@H]1S[C@@H](CC(=O)N(Cc2ccccc2)Cc2ccccc2)C(=O)N1CCCCc1ccc(cc1)C(O)=O
References
1. Aci-S?che S, Genest M, Garnier N. Ligand entry pathways in the ligand binding domain of PPAR? receptor. FEBS Lett. 2011 Aug 19;585(16):2599-603. doi: 10.1016/j.febslet.2011.07.014. PubMed PMID: 21782815.
2. Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM. Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci. 2008 Oct;105(2):418-28. doi: 10.1093/toxsci/kfn142. PubMed PMID: 18622026; PubMed Central PMCID: PMC2527639.
3. Genest D, Garnier N, Arrault A, Marot C, Morin-Allory L, Genest M. Ligand-escape pathways from the ligand-binding domain of PPARgamma receptor as probed by molecular dynamics simulations. Eur Biophys J. 2008 Apr;37(4):369-79. PubMed PMID: 17929009.
4. Sheu SH, Kaya T, Waxman DJ, Vajda S. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. Biochemistry. 2005 Feb 1;44(4):1193-209. PubMed PMID: 15667213.