Halenaquinone
| Code | Size | Price |
|---|
| TAR-T27526-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells.
CAS:
86690-14-4
Formula:
C20H12O5
Molecular Weight:
332.311
Purity:
0.98
SMILES:
C[C@@]12CCC(=O)c3coc(c13)C(=O)c1cc3C(=O)C=CC(=O)c3cc21
References
1. Tsukamoto S, Takeuchi T, Kawabata T, Kato H, Yamakuma M, Matsuo K, El-Desoky AH, Losung F, Mangindaan RE, de Voogd NJ, Arata Y, Yokosawa H. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5315-7. doi: 10.1016/j.bmcl.2014.09.043. PubMed PMID: 25278237.
2. Takaku M, Kainuma T, Ishida-Takaku T, Ishigami S, Suzuki H, Tashiro S, van Soest RW, Nakao Y, Kurumizaka H. Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51. Genes Cells. 2011 Apr;16(4):427-36. doi: 10.1111/j.1365-2443.2011.01494.x. PubMed PMID: 21375680.
3. Shih SP, Lee MG, El-Shazly M, Juan YS, Wen ZH, Du YC, Su JH, Sung PJ, Chen YC, Yang JC, Wu YC, Lu MC. Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities. Mar Drugs. 2015 May 20;13(5):3132-53. doi: 10.3390/md13053132. PubMed PMID: 26006712; PubMed Central PMCID: PMC4446623.
4. Wang J, Bourguet-Kondracki ML, Longeon A, Dubois J, Valentin A, Copp BR. Chemical and biological explorations of the electrophilic reactivity of the bioactive marine natural product halenaquinone with biomimetic nucleophiles. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1261-4. doi: 10.1016/j.bmcl.2010.12.056. PubMed PMID: 21256013.