Helenalin Acetate
| Code | Size | Price |
|---|
| TAR-T27532-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Helenalin Acetate is an anti-inflammatory and anti-cancer agent, disrupting the cooperation of CCAAT-box/enhancer-binding protein beta (C/EBP?) and co-activator p300.
CAS:
10180-86-6
Formula:
C17H20O5
Molecular Weight:
304.342
Purity:
0.98
SMILES:
C[C@@H]1C[C@H]2OC(=O)C(=C)[C@H]2[C@H](OC(C)=O)[C@@]2(C)[C@H]1C=CC2=O
References
1. Wulsten IF, Costa-Silva TA, Mesquita JT, Lima ML, Galuppo MK, Taniwaki NN, Borborema SET, Da Costa FB, Schmidt TJ, Tempone AG. Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones. Molecules. 2017 Apr 25;22(5). pii: E685. doi: 10.3390/molecules22050685. PubMed PMID: 28441357.
2. Jakobs A, Steinmann S, Henrich SM, Schmidt TJ, Klempnauer KH. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein ? (C/EBP?) and Co-activator p300. J Biol Chem. 2016 Dec 9;291(50):26098-26108. Epub 2016 Nov 1. PubMed PMID: 27803164; PubMed Central PMCID: PMC5207079.
3. Schomburg C, Schuehly W, Da Costa FB, Klempnauer KH, Schmidt TJ. Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships. Eur J Med Chem. 2013 May;63:313-20. doi: 10.1016/j.ejmech.2013.02.018. Epub 2013 Feb 26. PubMed PMID: 23501116.
4. Ramanandraibe V, Martin MT, Rakotondramanana DL, Mambu L, Ramanitrahasimbola D, Laba?ed M, Grellier P, Rasoanaivo P, Frappier F. Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities. J Nat Prod. 2005 May;68(5):800-3. PubMed PMID: 15921436.