Hippuristanol
| Code | Size | Price |
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| TAR-T27544-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hippuristanol is a potent steroid inhibitor of eukaryotic initiation factor 4A (eIF4A).
CAS:
80442-78-0
Formula:
C28H46O5
Molecular Weight:
462.671
Purity:
0.98
SMILES:
[H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@@]1(C[C@H](C)C(C)(C)O1)O2
References
1. Cencic R, Pelletier J. Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A. Translation (Austin). 2016 Jan 4;4(1):e1137381. doi: 10.1080/21690731.2015.1137381. eCollection 2016 Jan-Jun. Review. PubMed PMID: 27335721; PubMed Central PMCID: PMC4909409.
2. Raza F, Waldron JA, Quesne JL. Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence. Biochem Soc Trans. 2015 Dec;43(6):1227-33. doi: 10.1042/BST20150163. Review. PubMed PMID: 26614665.
3. Lindqvist L, Pelletier J. Inhibitors of translation initiation as cancer therapeutics. Future Med Chem. 2009 Dec;1(9):1709-22. doi: 10.4155/fmc.09.122. Review. PubMed PMID: 21425987.