Hirugen
| Code | Size | Price |
|---|
| TAR-T27545-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hirugen is a derivative of hirudin, which is an anticoagulant protein found in leeches.
CAS:
121822-23-9
Formula:
C65H91N13O28S
Molecular Weight:
1534.57
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(OS(O)(=O)=O)cc1)C(=O)N[C@@H](CC(C)C)C(O)=O
References
1. Glusa E. Desulfated hirugen (hirudin 54-65) induces endothelium-dependent relaxation of porcine pulmonary arteries. Thromb Haemost. 1994 Aug;72(2):318-21. PubMed PMID: 7530386.
2. Koh CY, Kumar S, Kazimirova M, Nuttall PA, Radhakrishnan UP, Kim S, Jagadeeswaran P, Imamura T, Mizuguchi J, Iwanaga S, Swaminathan K, Kini RM. Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors. PLoS One. 2011;6(10):e26367. doi: 10.1371/journal.pone.0026367. Epub 2011 Oct 28. PubMed PMID: 22053189; PubMed Central PMCID: PMC3203879.
3. Zavyalova E, Kopylov A. Multiple inhibitory kinetics reveal an allosteric interplay among thrombin functional sites. Thromb Res. 2015 Jan;135(1):212-6. doi: 10.1016/j.thromres.2014.11.005. Epub 2014 Nov 15. PubMed PMID: 25467079.
4. Zarpellon A, Celikel R, Roberts JR, McClintock RA, Mendolicchio GL, Moore KL, Jing H, Varughese KI, Ruggeri ZM. Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8628-33. doi: 10.1073/pnas.1017042108. Epub 2011 May 9. PubMed PMID: 21555542; PubMed Central PMCID: PMC3102361.