Hydroxypropyl-beta-cyclodextrin
| Code | Size | Price |
|---|
| TAR-T27563-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Hydroxypropyl-beta-cyclodextrin, also known as Hydroxypropyl-beta-cyclodextrin; THPB; HP-beta-CD; HPbCD; HP-beta-CyD; VTS-270; HPbetaCD; HPbetaCyD, is a drug candidate potentially for the treatment of Niemann-Pick type C diseases. In April 2009, hydroxypropyl-beta-cyclodextrin (HPbCD) was first approved.
CAS:
107745-73-3
Formula:
C54H96O36
Molecular Weight:
1321.326
Purity:
0.98
SMILES:
CC(O)COC[C@H]1OC2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)OC(O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)OC(O[C@H]1[C@@H](O)[C@H]2O)[C@H](O)[C@@H]7O)[C@H](O)[C@@H]6O)[C@H](O)[C@@H]5O)[C@H](O)[C@@H]4O)[C@H](O)[C@@H]3O
References
1. Li X, Yang M, Li Y, Gong W, Wang Y, Shan L, Shao S, Gao C, Zhong W. Formulation and characterization of ternary inclusion complex containing hydroxypropyl-?-cyclodextrin and meglumine for solubility enhancement of poorly water-soluble ST-246, an anti-smallpox drug. Curr Drug Deliv. 2016 Oct 3. PubMed PMID: 27697036.
2. Li P, Song J, Ni X, Guo Q, Wen H, Zhou Q, Shen Y, Huang Y, Qiu P, Lin S, Hu H. Comparison in toxicity and solubilizing capacity of hydroxypropyl-?-cyclodextrin with different degree of substitution. Int J Pharm. 2016 Sep 11;513(1-2):347-356. doi: 10.1016/j.ijpharm.2016.09.036. PubMed PMID: 27628782.
3. Khadka S, El Rassi Z. Postpolymerization modification of a hydroxy monolith precursor. Part III. Activation of poly(hydroxyethyl methacrylate-co-pentaerythritol triacrylate) monolith with epoxy functionalities followed by bonding of glycerol, polyamines, and hydroxypropyl-?-cyclodextrin for hydrophilic interaction and chiral capillary electrochromatography. Electrophoresis. 2016 Sep 9. doi: 10.1002/elps.201600326. PubMed PMID: 27611716.
4. Vartiainen V, Bimbo LM, Hirvonen J, Kauppinen EI, Raula J. Aerosolization, Drug Permeation and Cellular Interaction of Dry Powder Pulmonary Formulations of Corticosteroids with Hydroxypropyl-?-Cyclodextrin as a Solubilizer. Pharm Res. 2016 Sep 7. [Epub ahead of print] PubMed PMID: 27604893.