TargetMol

Imigliptin Dihydrochloride

Product Code:
 
TAR-T27598
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27598-5mg5mg£850.00
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TAR-T27598-50mg50mg£1,661.00
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TAR-T27598-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Imigliptin Dihydrochloride, a selective dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type II diabetes.
CAS:
1314944-07-4
Formula:
C21H26Cl2N6O
Molecular Weight:
449.38
Purity:
0.98
SMILES:
Cl.Cl.Cc1cc(N2CCC[C@@H](N)C2)c2n(Cc3ccccc3C#N)c(=O)n(C)c2n1

References

1. Liu D, Ma X, Liu Y, Zhou H, Shi C, Wu F, Jiang J, Hu P. Quantitative prediction of human pharmacokinetics and pharmacodynamics of imigliptin, a novel DPP-4 inhibitor, using allometric scaling, IVIVE and PK/PD modeling methods. Eur J Pharm Sci. 2016 Jun 30;89:73-82. doi: 10.1016/j.ejps.2016.04.020. Epub 2016 Apr 21. PubMed PMID: 27108678. 2. Liu Y, Liu D, Liu H, Song H, Song L, Yao X, Wu F, Shu C, Ma X, Zhou H, Jiang J, Hu P. Simultaneous determination of imigliptin and its three metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:300-12. doi: 10.1016/j.jchromb.2015.08.003. PubMed PMID: 26355270. 3. Shu C, Ge H, Song M, Chen JH, Zhou H, Qi Q, Wang F, Ma X, Yang X, Zhang G, Ding Y, Zhou D, Peng P, Shih CK, Xu J, Wu F. Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. doi: 10.1021/ml5001905. PubMed PMID: 25147615; PubMed Central PMCID: PMC4137375.