JG26
Code | Size | Price |
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TAR-T27654-1mg | 1mg | £152.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27654-5mg | 5mg | £268.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27654-10mg | 10mg | £367.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27654-25mg | 25mg | £570.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27654-50mg | 50mg | £781.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
JG26 is an ADAM17 inhibitor. JG26 inhibits AngII-induced EGFR transactivation and ERK activation in vascular smooth muscle cells (VSMCs).
CAS:
1464910-32-4
Formula:
C19H22Br2N4O6S
Molecular Weight:
594.28
Pathway:
Immunology/Inflammation|Proteases/Proteasome
Purity:
0.98
SMILES:
NC(=O)NCCC[C@@H](NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1)C(=O)NO
Target:
Immunology/Inflammation related|MMP
References
1. Pharmacological Inhibition of ADAM17 by a Human-Cross Reactive Antibody and Selective Inhibitor JG26 Prevents Vascular Fibrosis Induced by Angiotensin II in vivo and in vitro. Tatsuo Kawai, Steven J Forrester, Kunie Eguchi, Victor Rizzo, Satoru Eguchi, Hang Fai Kwok, Gillian Murphy and Armando Rossello. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;36:A557, originally published February 9, 2017