JN403
| Code | Size | Price |
|---|
| TAR-T27657-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27657-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27657-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
JN403 is a selective agonist of nicotinic acetylcholine receptor alpha7.
CAS:
942606-12-4
Formula:
C16H21FN2O2
Molecular Weight:
292.354
Purity:
0.98
SMILES:
Fc1ccccc1CCOC(=O)N[C@@H]1CN2CCC1CC2
References
1. Lilja AM, Malmsten L, R?jdner J, Voytenko L, Verkhratsky A, ?gren SO, Nordberg A, Marutle A. Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic ?7 Nicotinic Receptor Drugs. Neural Plast. 2015;2015:370432. doi: 10.1155/2015/370432. Epub 2015 Jul 15. PubMed PMID: 26257960; PubMed Central PMCID: PMC4518185.
2. Arias HR, De Rosa MJ, Berg? I, Feuerbach D, Bouzat C. Differential pharmacological activity of JN403 between ?7 and muscle nicotinic acetylcholine receptors. Biochemistry. 2013 Nov 26;52(47):8480-8. doi: 10.1021/bi4012572. Epub 2013 Nov 11. PubMed PMID: 24164482.
3. Chen SG, Gu RX, Dai H, Wei DQ. Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease. J Mol Graph Model. 2013 Feb;39:98-107. doi: 10.1016/j.jmgm.2012.11.008. Epub 2012 Nov 29. PubMed PMID: 23261879.
4. Ni R, Marutle A, Nordberg A. Modulation of ?7 nicotinic acetylcholine receptor and fibrillar amyloid-? interactions in Alzheimer's disease brain. J Alzheimers Dis. 2013;33(3):841-51. doi: 10.3233/JAD-2012-121447. PubMed PMID: 23042213.