JY-XHe-053
| Code | Size | Price |
|---|
| TAR-T27702-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27702-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27702-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
JY-XHe-053 is a selective modulator of GABAA receptors.
CAS:
612526-36-0
Formula:
C22H16FN3O2
Molecular Weight:
373.387
Purity:
0.98
SMILES:
CCOC(=O)c1ncn-2c1CN=C(c1ccccc1F)c1cc(ccc-21)C#C
References
1. Schwienteck KL, Li G, Poe MM, Cook JM, Banks ML, Stevens Negus S. Abuse-related effects of subtype-selective GABA(A) receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats. Psychopharmacology (Berl). 2017 Apr 1. doi: 10.1007/s00213-017-4615-8. [Epub ahead of print] PubMed PMID: 28365836.
2. Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM Jr, Cook JM, Furtm?ller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, Rowlett JK. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 2010 Dec;59(7-8):612-8. doi: 10.1016/j.neuropharm.2010.08.011. Epub 2010 Aug 18. PubMed PMID: 20727364; PubMed Central PMCID: PMC2963662.
3. Savi? MM, Majumder S, Huang S, Edwankar RV, Furtm?ller R, Joksimovi? S, Clayton T Sr, Ramerstorfer J, Milinkovi? MM, Roth BL, Sieghart W, Cook JM. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):376-86. doi: 10.1016/j.pnpbp.2010.01.004. Epub 2010 Jan 13. PubMed PMID: 20074611; PubMed Central PMCID: PMC2859624.