KF24345
| Code | Size | Price |
|---|
| TAR-T27728-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27728-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27728-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
KF24345 is an inhibitor of adenosine uptake.
CAS:
178750-21-5
Formula:
C31H38N6O5
Molecular Weight:
574.682
Purity:
0.98
SMILES:
CCOc1cc2nc(nc(N3CCC(CC3)n3c(=O)n(C)c4ccc(C)cc4c3=O)c2cc1OCC)N1CCOCC1
References
1. Hammond JR, Archer RG. Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1 H,3H)-quinazolinedione hydrochloride (KF24345) with the es and ei subtypes of equilibrative nucleoside transporters. J Pharmacol Exp Ther. 2004 Mar;308(3):1083-93. PubMed PMID: 14634039.
2. Noji T, Karasawa A, Kusaka H. [Pharmacological study on the effects of the adenosine uptake inhibitor KF24345 on inflammatory diseases]. Nihon Yakurigaku Zasshi. 2003 Aug;122(2):121-34. Review. Japanese. PubMed PMID: 12890898.
3. Noji T, Nan-ya K, Mizutani M, Katagiri C, Sano J, Takada C, Nishikawa S, Karasawa A, Kusaka H. KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice. Eur J Pharmacol. 2002 Nov 1;454(1):85-93. PubMed PMID: 12409009.
4. Noji T, Takayama M, Mizutani M, Okamura Y, Takai H, Karasawa A, Kusaka H. KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. J Pharmacol Exp Ther. 2002 Jan;300(1):200-5. PubMed PMID: 11752117.