sPLA2 inhibitor 1
| Code | Size | Price |
|---|
| TAR-T27731-5mg | 5mg | £1,390.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
KH064 is a sPLA2-IIA inhibitor of oral activity.
CAS:
393569-31-8
Formula:
C31H37NO4
Molecular Weight:
487.64
Purity:
0.98
SMILES:
OC(=O)CC[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCCc1ccccc1
References
1. Kim RR, Malde AK, Nematollahi A, Scott KF, Church WB. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human group IIA phospholipase A(2). Proteins. 2017 Jan 5. doi: 10.1002/prot.25235. [Epub ahead of print] PubMed PMID: 28056488.
2. Yang X, Sheng W, Ridgley DM, Haidekker MA, Sun GY, Lee JC. Astrocytes regulate ?-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2. Neuroscience. 2015 Aug 6;300:508-17. doi: 10.1016/j.neuroscience.2015.05.052. PubMed PMID: 26037803; PubMed Central PMCID: PMC4485573.
3. Iyer A, Lim J, Poudyal H, Reid RC, Suen JY, Webster J, Prins JB, Whitehead JP, Fairlie DP, Brown L. An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes. 2012 Sep;61(9):2320-9. doi: 10.2337/db11-1179. PubMed PMID: 22923652; PubMed Central PMCID: PMC3425408.
4. Levick S, Loch D, Rolfe B, Reid RC, Fairlie DP, Taylor SM, Brown L. Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats. J Immunol. 2006 Jun 1;176(11):7000-7. PubMed PMID: 16709861.