KR-31378
| Code | Size | Price |
|---|
| TAR-T27739-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27739-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27739-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
KR-31378, a K(ATP) channel activator, is used potentially for the treatment of ocular hypertension and glaucoma.
CAS:
335381-68-5
Formula:
C22H27N5O4
Molecular Weight:
425.489
Purity:
0.98
SMILES:
COC(OC)[C@@]1(C)Oc2ccc(N)cc2[C@@H](NC(NC#N)=N/Cc2ccccc2)[C@@H]1O
References
1. Choi A, Choi JS, Yoon YJ, Kim KA, Joo CK. KR-31378, a potassium-channel opener, induces the protection of retinal ganglion cells in rat retinal ischemic models. J Pharmacol Sci. 2009 Apr;109(4):511-7. PubMed PMID: 19372634.
2. Hwang GS, Oh KS, Koo HN, Seo HW, You KH, Lee BH. Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure. Eur J Pharmacol. 2006 Jul 1;540(1-3):131-8. PubMed PMID: 16729997.
3. Lee CH, Choi KY, Kim YJ, Kim WG. Neuroprotective effect of KR-31378, a novel potassium channel activator, on spinal cord ischemic injury in rabbits. J Invest Surg. 2005 Nov-Dec;18(6):297-304. PubMed PMID: 16319050.
4. Kim MY, Lee S, Yi KY, Yoo SE, Lee DH, Lim H, Kim HS, Lee SH, Baik EJ, Moon CH, Jung YS. Protective effect of KR-31378 on oxidative stress in cardiac myocytes. Arch Pharm Res. 2005 Dec;28(12):1358-64. PubMed PMID: 16392669.